Dr. Shagufta Parveen
Assistant Professor
Manipal Institute of Regenerative Medicine
Qualification: PhD
CURRENT ACADEMIC ROLE & RESPONSIBILITIES
Assistant Professor in the Manipal Institute of Regenerative Medicine at Manipal Academy of Higher Education.
SUBJECTS CURRENTLY TEACHING
| Subject | Semester / Year |
|---|---|
| Biochemistry | I Semester |
| Developmental Biology | I Semester |
| Molecular Biology | I Semester |
| Molecular Techniques | II Semester |
| Immunology | II Semester |
| Application of Stem Cells | III Semester |
ACADEMIC QUALIFICATIONS
| Degree | Specialisation | Institute | Year of passing |
|---|---|---|---|
| MSc | Microbiology | Bangalore University | 2000 |
Experience
| Institution / Organisation | Designation | Role | Tenure |
|---|---|---|---|
| Manipal Institute of Regenerative Medicine Manipal Academy of Higher Education (MAHE) | Assistant Professor | Teaching | 16+ Years |
| St Josephs University | Lecturer | Teaching | 7 Months |
| PESIAS | Lecturer | Teaching | 6+ years |
Research Focus:
I am extremely passionate about pluripotent stem cell research. The mere plethora of research that can be conducted with PSCs fascinates me. I have channeled this interest into basic research by using induced PSCs as my principal cellular system. PSCs have inherent potential to transform into a myriad of cell types which I exploit to understand fundamental cellular and molecular mechanisms of early embryonic development, development malformations, cellular shapes and differentiation of cells from one type to another. I am presently working on the following areas regarding human development and disease.
1. Generation of iPSCs from cells isolated from individuals with developmental disorders like fetal death, neural tube defects and Turners syndrome.
2. Modelling Neural tube defects using organoids.
3. Modelling bicuspid aortic valve using iPSC derived cellular models.
4. Generation of blastoid/ gastruloid models to study implantation failures.
5. Wound healing using mesenchymal cell derived exosomes.
AREAS OF INTEREST, EXPERTISE AND RESEARCH
Area of Interest
Disease modelling and correction in pluripotent stem cells
Area of Expertise
Pluripotent stem cells and reprogramming
Area of Research
Generation of induced pluripotent stem cells
1. Parveen, S., Panicker, M. M. & Gupta, P. K. Lab resource: Stem cell line: Generation of an induced pluripotent stem cell line from chorionic villi of a Turner syndrome spontaneous abortion. Stem Cell Res. 19, 12–16 (2016). https://doi.org/10.1016/j.scr.2016.12.016
2. Parveen, S. Establishment and characterization of induced pluripotent stem cells from placental mesenchymal stromal cells. Stem Cell Res. 27, 15–20 (2018). https://doi.org/10.1016/j.scr.2017.12.008
3. Parveen, S., Singh, S. P., Panicker, M. M. & Gupta, P. K. Amniotic membrane as novel scaffold for human iPSC-derived cardiomyogenesis. Vitr. Cell. Dev. Biol. - Anim. (2019). https://doi.org/10.1007/s11626-019-00321-y
4. Shivaraj, A. & Parveen, S. Generation of integration free human iPSC line SORMi002-A from neonatal foreskin fibroblasts. Stem Cell Res. 40, 101534 (2019). https://doi.org/10.1016/j.scr.2019.101534
5. Nivedha Veerasubramanian, Vaishnavi Karthikeyan, Sridevi Hegde, Anandh Dhanushkodi, Shagufta Parveen. JoVE62240 "Generation of induced pluripotent stem cells from Turner Syndrome (45XO) fetal cells for downstream modelling of associated neurological deficits" Journal of Visualized Experiments JOVE https://doi.org:10.3791/62240