Research Focus:

We are interested in understanding the Mechanism and Patho-physiology of amino acid storage-homeostasis in response to extracellular environment involving lysosome: Lysosomes are key organelle for cellular protein degradation. Lysosomal malfunction is a major driver for different age-related diseases including, neurodegeneration, cancer, and storage disorders, highlighting the importance of this organelle in cellular and patho-physiological contexts. Apart from the ‘garbage-disposal’ role of lysosomes, the newly-emerging field is establishing this organelle as the major signaling hub for amino acid homeostasis. Upon amino acid generation within lysosomal lumen, how the itinerary (trafficking-compartmentalization-storage-utilization), fate and function of this lysosomally-born amino acids are regulated under dynamic nutrient composition in the outer milieu, is an uncharted territory of Cell Biology. Our work is the first-ever effort to shed light on the fundamental and patho-physiological aspect of environment-guided lysosomal amino acid homeostasis. Along the line, we have discovered a novel lysosomal amino acid storage-homeostasis pathway in cell functioning in response to extracellular environment.

We are currently focusing on:

1. Molecular mechanism of lysosomal amino acid storage-homeostasis pathway

2. Molecular mechanism of essential amino acid homeostasis in cell in varying extracellular amino acid composition

3. Patho-physiological significance of the novel lysosomal amino acid storage-homeostasis pathway

Publication:

Google Scholar Link: https://scholar.google.com/citations?user=Wyu1_9gAAAAJ&hl=en

Scopus Link: https://www.scopus.com/authid/detail.uri?authorId=12762699000

Lab webpage link: https://lysobio.weebly.com/