Dr. Aditi Gupta

Assistant Professor

Department of Clinical Embryology

CURRENT ACADEMIC ROLE & RESPONSIBILITIES

    Role- Assistant Professor, Department of Reproductive Science

    Responsibilities-

    1. Involved in teaching and mentoring postgraduate students of M.Sc. Reproductive Genetics course

    2. Recognized PhD guide from MAHE, Manipal

    3. Involved in thesis guidance of master’s course students and Ph.D. scholars’ supervision

    4. Involved in research on the genetics of infertility disorders and congenital defects, involved in applying for grants and procuring funding as principal investigator for projects

SUBJECTS CURRENTLY TEACHING

Subject Semester / Year
Reproductive Genetics I, II, III

ACADEMIC QUALIFICATIONS

Degree Specialisation Institute Year of passing
Ph. D. Human Genetics University of Delhi 06/2016
M.Sc. Genetics University of Delhi 06/2010
B.Sc. Biochemistry Hons. University of Delhi 06/2008

Experience

Institution / Organisation Designation Role Tenure
Strand Life Sciences India Pvt. Ltd., Bangalore, Karnataka Senior Scientist II Research August 2021- July 2023
Dana-Farber Cancer Institute, Boston, MA, USA Postdoctoral Research Fellow Research May 2019- July 2021
Mayo Clinic, Rochester, MN, USA Postdoctoral Research Fellow Research Sep 2016- May 2019
All India Institute of Medical Sciences, New Delhi Research Associate Research Nov 2015- Sep 2016

Name of the project: Uncovering genetic causes for familial cases of female infertility disorders

Principal investigator: Dr. Aditi Gupta

Funding agency: Intramural funding from MAHE

Overview: This project involves investigating families with multiple women affected with infertility-associated debilitating conditions such as endometriosis and subjecting them to whole exome sequencing (WES) to help identify potential monogenic causes of the disease. Endometriosis is an estrogen‑dependent severe gynecological disease characterized by chronic pain, inflammation and impaired fertility. This debilitating condition affects about 10% women of reproductive age, which accounts for ~247 million women globally and ~42 million women in India, thus a huge public burden and extremely critical to investigate its etiology to find novel diagnostics and therapeutics.

AREAS OF INTEREST, EXPERTISE AND RESEARCH

Area of Interest

Reproductive Genetics

Area of Expertise

Human Genetics, Medical Genomics

Area of Research

Rare genetic disorders, Congenital defects, infertility related disorders

Professional Affiliations & Contributions

Contributions-

Projects funded- 1

PhD students currently guiding- 1

Postgraduate M.Sc. Dissertation students guided- 2

 

NCBI link -https://www.ncbi.nlm.nih.gov/myncbi/aditi.gupta.8/bibliography/public/

Key Publications- 1. Lampson BL, Gupta A, Tyekucheva S, Mashima K, Petráčková A, Wang Z, Wojciechowska N, Shaughnessy CJ, Baker PO, Fernandes SM, Shupe S, Machado JH, Fardoun R, Kim AS, Brown JR. Rare Germline ATM Variants Influence the Development of Chronic Lymphocytic Leukemia. J Clin Oncol. 2023 Feb 10;41(5):1116-1128. doi: 10.1200/JCO.22.00269. Epub 2022 Oct 31. PubMed PMID: 36315919; PubMed Central PMCID: PMC9928739. 2. Gupta A, Dsouza NR, Zarate YA, Lombardo R, Hopkin R, Linehan AR, Simpson J, McCarrier J, Agre KE, Gavrilova RH, Stephens MC, Grothe RM, Monaghan KG, Xie Y, Basel D, Urrutia RA, Cole CR, Klee EW, Zimmermann MT. Genetic variants in DGAT1 cause diverse clinical presentations of malnutrition through a specific molecular mechanism. Eur J Med Genet. 2020 Apr;63(4):103817. doi: 10.1016/j.ejmg.2019.103817. Epub 2019 Nov 25. PubMed PMID: 31778854. 3. Gupta A, Zimmermann MT, Wang H, Broski SM, Sigafoos AN, Macklin SK, Urrutia RA, Clark KJ, Atwal PS, Pignolo RJ, Klee EW. Molecular characterization of known and novel ACVR1 variants in phenotypes of aberrant ossification. Am J Med Genet A. 2019 Sep;179(9):1764-1777. doi: 10.1002/ajmg.a.61274. Epub 2019 Jun 26. PubMed PMID: 31240838. 4. Gupta A, Juyal G, Sood A, Midha V, Yamazaki K, Vich Vila A, Esaki M, Matsui T, Takahashi A, Kubo M, Weersma RK, Thelma BK. A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis GWAS hits, underscores their potential role in disease susceptibility. Eur J Hum Genet. 2016 Jan;25(1):111-122. doi: 10.1038/ejhg.2016.131. Epub 2016 Oct 19. PubMed PMID: 27759029; PubMed Central PMCID: PMC5159766. 5. Gupta A, Thelma BK. Identification of critical variants within SLC44A4, an ulcerative colitis susceptibility gene identified in a GWAS in north Indians. Genes Immun. 2016 Mar;17(2):105-9. doi: 10.1038/gene.2015.53. Epub 2016 Jan 7. PubMed PMID: 26741288.