Abstract Most of the times it is difficult for the clinicians to confirm the clinical diagnosis without investigations as the clinical picture of oral lesions may be similar to many other conditions. Hence, appropriate clinical examination, coupled with adiological and histopathological investigations could aid in appropriate diagnosis and anagement of the lesions. This article elaborates on differential diagnosis for pericoronal radiolucencies affecting the jaws in a patient presented for a routine dental examination. Differential diagnosis helps us to diagnose a specific lesion by eliminating those lesions which appear clinically similar. As advanced diagnostic aids are available, decision-making has become much easier for these lesions.